Related Experiment Video
Updated: Feb 23, 2026
Author Spotlight: Exploring Olfactory Influences on Corticospinal Excitability - Insights and Innovations in Neurological Research
Published on: January 19, 2024
Short inter-stimulus intervals can be used for olfactory electroencephalography in patients of varying olfactory
K L Whitcroft1, M Aziz2, I Croy3
1Smell & Taste Clinic, Department of ORL, TU Dresden, Dresden, Germany; UCL Ear Institute, London, UK; Centre for the Study of the Senses, School of Advanced Study, London, UK.
Abstract:
Use of chemosensory event-related potentials (ERPs) is limited by relatively poor signal-to-noise ratios (SNRs). We hypothesized that by reducing the standard inter-stimulus interval (ISI), the increased number of trial repetitions possible may increase SNR. In order to further investigate this, we performed the largest study to date assessing chemosensory ERP using short and long ISIs in 101 participants of varying olfactory function. Using rose odor (phenylethylalcohol, PEA) as a relatively selective olfactory stimulant, we found no significant difference in the proportion of individuals in whom ERPs were recorded using short or long ISIs. This was true in normosmic, hyposmic and functionally anosmic individuals. We also demonstrated significantly increased SNR using short PEA-ISIs, in the normosmic and functionally anosmic groups. Comparing between groups of different olfactory function, hyposmic patients achieved faster onsets and greater amplitudes than normosmics under the PEA-10s protocol. This could be due to increased stimulus attendance, but requires confirmation with further research.
