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Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine
Published on: February 17, 2018
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[Acute and chronic heart failure].
K-P Kresoja1,2, G Schmidt1, B Kherad1
1Medizinische Klinik mit Schwerpunkt Kardiologie, Campus Virchow-Klinikum (CVK), Charité - Universitätsmedizin Berlin, Augustenburgerplatz 1, 13353, Berlin, Deutschland.
Herz
|September 6, 2017
Summary
New heart failure guidelines include sacubitril/valsartan (LCZ 696) and address comorbidities. Updated recommendations also cover iron therapy, cardiac devices, and mechanical support for acute heart failure.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Current chronic heart failure (CHF) initial therapy includes diuretics, ACE inhibitors, beta-blockers, and MRAs.
- The 2016 European Society of Cardiology (ESC) guidelines introduced novel therapeutic agents for CHF.
Purpose of the Study:
- To review recent advancements in the medical and device therapy of chronic and acute heart failure.
- To highlight the role of new agents like sacubitril/valsartan (LCZ 696) and address comorbidities.
Main Methods:
- Review of new European Society of Cardiology (ESC) guidelines.
- Analysis of subgroup data for sacubitril/valsartan (LCZ 696).
- Inclusion of data on intravenous iron, cardiac devices, and mechanical circulatory support.
Main Results:
- Sacubitril/valsartan (LCZ 696) demonstrates benefits across various comorbidities including renal insufficiency, diabetes, and hypotension.
- New data support intravenous iron substitution and provide updated indications for implantable cardioverter-defibrillators (ICDs) and cardiac resynchronization therapy (CRT).
- Medical therapy for acute heart failure remains limited, with mechanical circulatory support, such as extracorporeal membrane oxygenation (ECMO), recommended for non-responders.
Conclusions:
- Angiotensin-receptor-neprilysin inhibitors represent a significant advancement in chronic heart failure management.
- Comprehensive updates address device therapy and novel treatments for heart failure patients with complex conditions.
- Mechanical circulatory support is crucial for managing acute heart failure when medical therapy fails.
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