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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

[Relation between arterial hypertension and plasma lipoproteins: the Australian experience]

G J MacDonald

    Archives Des Maladies Du Coeur Et Des Vaisseaux
    |April 1, 1987
    PubMed

    Insights

    Common anti-hypertensive treatments, including beta-blockers, can negatively impact high-density lipoprotein (HDL) cholesterol levels. This study observed these unfavorable changes in obese hypertensive patients and the general population.

    Area of Science:

    • Cardiovascular Medicine
    • Pharmacology

    Context:

    • Anti-hypertensive medications are widely prescribed.
    • Clinical trials suggest some treatments adversely affect HDL-cholesterol.
    • The impact on the general population is less understood.

    Purpose:

    • To investigate if common anti-hypertensive therapies cause unfavorable changes in high-density lipoprotein (HDL)-cholesterol levels in a general population.
    • To compare these effects in individuals with normal blood pressure, unrecognized hypertension, and those undergoing treatment.
    • To specifically examine the effects of beta-blockers in obese hypertensive patients.

    Summary:

    • The study divided participants into three groups: normal blood pressure, unrecognized hypertension, and those on anti-hypertensive treatment.
    • Obese hypertensive patients treated with beta-blockers showed unfavorable changes in HDL-cholesterol levels.
    • These changes were similar to those observed in the general population using common anti-hypertensive therapies.

    Impact:

    • Findings suggest that widely used anti-hypertensive treatments may negatively impact HDL-cholesterol across different patient groups.
    • Highlights the need for monitoring lipid profiles in patients receiving these medications.
    • Informs clinical practice regarding potential side effects of hypertension management.

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