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Alprazolam dependence in mice.

E J Gallaher, C J Jacques, L E Hollister

    Alcohol and Drug Research
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Alprazolam (a benzodiazepine) causes withdrawal symptoms in mice, similar to diazepam but with a faster onset and shorter duration. This mouse model helps study benzodiazepine dependence and withdrawal across the drug class.

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    Area of Science:

    • Pharmacology
    • Neuroscience
    • Animal Models

    Background:

    • Benzodiazepines are widely prescribed for anxiety and insomnia.
    • Understanding benzodiazepine dependence and withdrawal is crucial for clinical practice.
    • Previous studies established a mouse model for diazepam withdrawal.

    Purpose of the Study:

    • To investigate alprazolam-induced dependence and withdrawal in mice.
    • To characterize the time course and intensity of alprazolam withdrawal.
    • To assess the generalizability of the benzodiazepine dependence model in mice.

    Main Methods:

    • Mice were fed diets containing 0.025% alprazolam for 1, 2, or 4 weeks.
    • Withdrawal symptoms were observed after switching to regular food.
    • A separate experiment involved singly housed mice to assess the impact of social housing on withdrawal.

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  • Cannibalism was noted as a side effect in group-housed, treated mice.

    • Main Results:

    • Alprazolam treatment led to weight gain and apparent health in mice.
    • Alprazolam-treated mice exhibited withdrawal reactions upon cessation of the drug.
    • Alprazolam withdrawal was qualitatively similar to diazepam withdrawal but less intense, with a faster onset and shorter duration.
    • Singly housed mice showed similar withdrawal patterns without the complication of cannibalism.

    Conclusions:

    • The mouse model of benzodiazepine dependence appears generalizable to alprazolam.
    • Alprazolam withdrawal in mice has a distinct, shorter time course compared to diazepam.
    • This model can differentiate withdrawal characteristics among various benzodiazepines.