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[Vitamin D/vitamin D receptor, autophagy and inflammation relevant diseases]

Aimei Li1, Wei Zhang1, Hao Zhang1

  • 1Department of Nephrology, Third Xiangya Hospital, Central South University, Changsha 410013, China.

Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences
|September 6, 2017
PubMed

Insights

Vitamin D and its receptor (VDR) influence cellular processes like autophagy, impacting inflammation and disease. This interaction is crucial for maintaining cell health and preventing diseases like cancer and autoimmune disorders.

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Endocrinology

Background:

  • Vitamin D and its receptor (VDR) regulate critical physiological processes, including metabolism, immunity, and cancer prevention.
  • Autophagy, a cellular degradation pathway, is essential for maintaining cellular homeostasis and is implicated in various diseases.
  • Dysfunctional autophagy is linked to pathological conditions such as inflammation, infection, and cancer.

Purpose of the Study:

  • To explore the intricate relationship between vitamin D/VDR signaling and autophagy.
  • To elucidate how vitamin D/VDR modulates autophagy in the context of inflammation and disease.

Main Methods:

  • Review of existing literature on vitamin D/VDR, autophagy, and their interplay.
  • Analysis of studies investigating the molecular mechanisms connecting vitamin D/VDR and autophagy pathways.

Main Results:

  • Vitamin D/VDR signaling influences multiple stages of the autophagy process.
  • Vitamin D/VDR plays a role in regulating inflammation through autophagy modulation.
  • The interplay between vitamin D/VDR and autophagy is significant in autoimmune diseases, diabetes, cardiovascular diseases, and cancer.

Conclusions:

  • Vitamin D/VDR and autophagy are key regulators of cellular processes and disease pathogenesis.
  • Targeting the vitamin D/VDR-autophagy axis presents potential therapeutic strategies for inflammatory and other diseases.

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