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Related Concept Videos

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
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Alzheimer's Disease: Treatment01:22

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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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Dementia01:30

Dementia

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Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
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Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Amyloid Fibrils03:03

Amyloid Fibrils

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

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Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
 Glutamate and Synaptic Plasticity
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Related Experiment Video

Updated: Feb 23, 2026

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
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Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

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Alzheimer's disease.

C A Lane1, J Hardy2, J M Schott1

  • 1Dementia Research Centre, UCL Institute of Neurology, London, UK.

European Journal of Neurology
|September 6, 2017
PubMed
Summary
This summary is machine-generated.

Alzheimer's disease (AD) is a major cause of dementia. This review covers AD epidemiology, genetics, pathology, and pathogenesis, exploring new prevention strategies beyond current treatments.

Keywords:
Alzheimer's diseaseepidemiologygeneticspathogenesispathologytreatment

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Area of Science:

  • Neurology
  • Gerontology
  • Public Health

Background:

  • Alzheimer's disease (AD) is the most prevalent cause of dementia, posing significant global health challenges.
  • Understanding AD's epidemiology, genetics, and pathology is crucial for developing effective interventions.

Purpose of the Study:

  • To provide a comprehensive review of Alzheimer's disease.
  • To outline current knowledge on AD's epidemiology, genetics, pathology, and pathogenesis.
  • To discuss clinical presentation, treatment strategies, and emerging preventive approaches.

Main Methods:

  • Literature review synthesizing current research on Alzheimer's disease.
  • Analysis of epidemiological data, genetic factors, and pathological hallmarks.
  • Examination of clinical manifestations and therapeutic interventions.

Main Results:

  • AD pathogenesis involves a protracted preclinical phase.
  • Enhanced understanding of AD mechanisms is shifting focus towards prevention.
  • Current treatments primarily manage symptoms, highlighting the need for disease-modifying therapies.

Conclusions:

  • A deeper comprehension of Alzheimer's disease pathogenesis, including its preclinical stages, is pivotal.
  • Future therapeutic strategies aim to transition from treating AD symptoms to preventing its onset.
  • Continued research is essential for combating the growing burden of Alzheimer's disease worldwide.