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Updated: Jun 8, 2026
Non-invasive Assessment of Microvascular and Endothelial Function
Published on: January 29, 2013
Urinary liver-type fatty acid-binding protein is associated with subendocardial viability ratio in middle- and
Keisei Kosaki1, Atsuko Kamijo-Ikemori2,3, Takeshi Sugaya2,4
1a Graduate School of Comprehensive Human Sciences , University of Tsukuba , Ibaraki , Japan.
Background:
To identify one of the physiological underlying mechanisms of the predictive effects of urinary liver-type fatty acid-binding protein (L-FABP) for the onset of cardiovascular disease (CVD), we investigated the relationship between urinary L-FABP levels and subendocardial viability ratio (SEVR), a marker of myocardial perfusion, in middle- and older-aged adults.
Methods:
This was a cross-sectional study of 249 middle- and older-aged adults (aged 46-83 years). We measured urinary L-FABP levels and central hemodynamic parameters, including SEVR, calculated by pulse wave analysis using an applanation tonometry.
Results:
In the participants stratified in accordance with the tertiles of urinary L-FABP levels, SEVR decreased in a stepwise fashion with increasing tertiles (p < 0.001). Furthermore, this association remains significant after the consideration of various confounders. On the contrary, urinary albumin levels were not independently related with SEVR.
Conclusion:
Our results demonstrated that urinary L-FABP levels were independently associated with the SEVR of the middle- and older-aged adults. This result suggests that the increase in urinary L-FABP levels even within the normal range might be related to the decrease in myocardial perfusion (SEVR).
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