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Related Experiment Video

Updated: Jan 5, 2026

Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice

Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice

Published on: February 3, 2023

Bone marrow adipocytes.

Mark C Horowitz¹, Ryan Berry¹, Brandon Holtrup²

¹a Department of Orthopaedics and Rehabilitation , Yale University School of Medicine , New Haven , CT , USA.

|September 6, 2017

Summary

This summary is machine-generated.

Bone marrow adipocytes, once overlooked, are now understood to influence whole-body metabolism and interact with other cells. This distinct adipose tissue depot changes with age and physiological signals.

Keywords:

adipocyte progenitors lineage tracing marrow adipocyte differentiation marrow adipose tissue marrow fat

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Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice

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Dual Effects of Melanoma Cell-derived Factors on Bone Marrow Adipocytes Differentiation

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Published on: August 23, 2018

Area of Science:

Bone Biology
Metabolic Research
Adipose Tissue Biology

Background:

Adipocytes in human bone marrow were identified over a century ago.
Their origin, function, and interactions within the bone marrow remain understudied.
A persistent paradigm attributes little functional significance to these cells.

Purpose of the Study:

To review recent findings on bone marrow adipocytes.
To highlight their distinct characteristics compared to other adipocyte types.
To explore their interactions with intra-marrow and systemic cells.

Main Methods:

Literature review of recent research on marrow adipose tissue.
Analysis of studies investigating adipocyte origin and function.
Examination of data on adipokine secretion and metabolic effects.

Main Results:

Marrow adipose tissue (MAT) increases with age and physiological stimuli.
Bone marrow adipocytes secrete specific adipokines influencing whole-body metabolism.
These adipocytes are metabolically and developmentally distinct from white, brown, and beige fat cells.

Conclusions:

Bone marrow is a unique adipose depot with significant physiological roles.
Marrow adipocytes actively interact with other bone marrow cells.
MAT influences systemic metabolism and warrants further investigation.