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Related Experiment Videos

Passive Picoinjection Enables Controlled Crystallization in a Droplet Microfluidic Device.

Shunbo Li1, Muling Zeng1, Thembaninkosi Gaule2

  • 1School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK.

Small (Weinheim an Der Bergstrasse, Germany)
|September 6, 2017
PubMed
Summary

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This study introduces a novel microfluidic device for studying crystallization of sparingly soluble compounds. Its unique picoinjector design enables reproducible, long-term experiments, overcoming previous limitations in microfluidic crystallization research.

Area of Science:

  • Chemical Engineering
  • Materials Science
  • Physical Chemistry

Background:

  • Segmented flow microfluidics are useful for studying crystallization.
  • Current devices face challenges with fouling and reproducibility for sparingly soluble compounds.
  • Existing methods struggle with in-channel precipitation at low supersaturations.

Purpose of the Study:

  • To present a novel microfluidic device overcoming limitations for studying crystallization of sparingly soluble compounds.
  • To demonstrate a picoinjector design for direct, passive solution injection into flowing droplets.
  • To achieve reproducible crystallization studies over long run-times at high supersaturations.

Main Methods:

  • Development of a microfluidic device featuring a novel picoinjector.
Keywords:
calcium carbonatecrystallizationdevice foulingmicrofluidicspicoinjector

Related Experiment Videos

  • Utilizing a Venturi junction for passive solution injection into droplets without an electric field.
  • Demonstration using calcium carbonate crystallization at high supersaturations.

    • Main Results:

    • The picoinjector design successfully overcomes device fouling and reproducibility issues.
    • Passive injection into flowing droplets is achieved via a Venturi junction.
    • Highly reproducible results for calcium carbonate crystallization were obtained over long run-times and high supersaturations.

    Conclusions:

    • The novel microfluidic device enables the study of crystallization for low solubility compounds.
    • The passive picoinjector design offers broad applicability in multistep reactions and reaction dynamics.
    • This work advances microfluidic applications in materials science and chemical engineering.