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Perfluorocarbons as oxygen-transport fluids.

K C Lowe

    Comparative Biochemistry and Physiology. A, Comparative Physiology
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Perfluorocarbons (PFCs) and their emulsions show promise as oxygen-transport fluids for various medical applications. Research explores their potential as red blood cell substitutes and in therapies like liquid ventilation and organ perfusion.

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    Area of Science:

    • Biomedical Engineering
    • Biochemistry
    • Medical Sciences

    Background:

    • Perfluorocarbons (PFCs) are synthetic compounds with unique oxygen-carrying capabilities.
    • PFC emulsions are being investigated for their potential in various medical applications due to their inertness and oxygen solubility.

    Purpose of the Study:

    • To provide an overview of biological applications of perfluorocarbon emulsions as oxygen-transport fluids.
    • To discuss the properties, preparation, and physiological assessment of PFC emulsions.
    • To review the therapeutic potential of PFCs in areas such as liquid ventilation, decompression sickness, organ perfusion, and as NMR contrast agents.

    Main Methods:

    • Review of existing literature on perfluorocarbon properties and applications.
    • Analysis of experimental data from animal and human studies involving PFC emulsions.

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  • Discussion of the potential of PFCs as red blood cell substitutes and comparison with other oxygen-carrying agents.

    • Main Results:

    • PFC emulsions demonstrate potential for oxygen transport and various therapeutic interventions.
    • Studies indicate PFC emulsions can be evaluated for safety and efficacy in preclinical and clinical settings.
    • The potential of PFCs as effective red blood cell substitutes is a key area of investigation.

    Conclusions:

    • Perfluorocarbon emulsions represent a promising area of research for oxygen-transport and therapeutic applications.
    • Further research and clinical trials are necessary to fully establish the value of PFCs in medicine.
    • PFCs may offer viable alternatives or adjuncts to traditional treatments and blood products.