Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PLGA-PEG Nano-Adjuvant-Delivered ClfA Vaccine Elicits IL-17A-Mediated Neutrophil Activation to Confer Complete Protection Against Methicillin-Resistant <i>Staphylococcus aureus</i>.

International journal of nanomedicine·2026
Same author

A living therapeutic platform for localized in situ modulation of macrophage pyroptosis ameliorates GVHD while preserving GVL.

Journal of nanobiotechnology·2026
Same author

Rational Combination of Dominant and Subdominant Antigens with Nanoadjuvant Elicits Durable Immunity Against <i>Staphylococcus aureus</i>.

Vaccines·2026
Same author

Correction: Synergistic nano-vaccine strategy for comprehensive activation of adaptive and innate immunity against <i>Staphylococcus aureus</i> infection.

Frontiers in immunology·2025
Same author

Synergistic nano-vaccine strategy for comprehensive activation of adaptive and innate immunity against <i>Staphylococcus aureus</i> infection.

Frontiers in immunology·2025
Same author

Antigen-Dependent Adjuvanticity of Poly(lactic-co-glycolic acid)-polyethylene Glycol 25% Nanoparticles for Enhanced Vaccine Efficacy.

Vaccines·2025

Related Experiment Video

Updated: Feb 23, 2026

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
09:45

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers

Published on: October 28, 2015

8.9K

Ternary cocktail nanoparticles for sequential chemo-photodynamic therapy.

Li Fan1, Saisai Zhao2, Qian Yang3

  • 1Department of Pharmaceutical analysis, School of Pharmacy, and The State Key Laboratory of Cancer Biology (CBSKL), The Fourth Military Medical University, 169th Changle West Road, Xi'an, Shaanxi, 710032, China.

Journal of Experimental & Clinical Cancer Research : CR
|September 7, 2017
PubMed
Summary

This study introduces a novel ternary cocktail nanoparticle system for synergistic chemo-photodynamic therapy. The system precisely delivers drugs sequentially, enhancing cancer treatment efficacy and safety.

Keywords:
Chemo-photodynamic therapyDocetaxelGemcitabine hydrochlorideSelf-decomposable NPsSequential release

More Related Videos

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

9.5K
Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
08:57

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice

Published on: October 5, 2017

11.5K

Related Experiment Videos

Last Updated: Feb 23, 2026

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
09:45

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers

Published on: October 28, 2015

8.9K
Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

9.5K
Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
08:57

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice

Published on: October 5, 2017

11.5K

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Sequential combination therapies show enhanced efficacy in cancer treatment.
  • Photodynamic therapy (PDT) and chemotherapy combinations are particularly promising.
  • Developing advanced drug delivery systems is crucial for synergistic cancer treatment.

Purpose of the Study:

  • To develop a ternary cocktail nanoparticle (NP) delivery system for synergistic chemo-photodynamic therapy.
  • To achieve multi-level programmable PDT and timed chemotherapy drug release.
  • To create a precise sequential release platform for enhanced cancer cure.

Main Methods:

  • Encapsulated methylene blue (MB) in NPs for programmable PDT with distinct release profiles.
  • Loaded gemcitabine hydrochloride (GM) and Docetaxel (DTX) onto NPs for sequential chemotherapy.
  • Utilized self-decomposable NPs with tailored configurations for controlled drug release intervals.

Main Results:

  • Demonstrated maximized multi-level programmable PDT through pulsed MB release.
  • Achieved a 12-hour release time lag between GM and DTX, proving optimal for synergistic effects.
  • Validated in vitro and in vivo efficacy of the sequential release strategy.

Conclusions:

  • The developed ternary cocktail NPs offer a promising platform for efficient and safe chemo-photodynamic therapy.
  • Precise sequential drug release enhances therapeutic outcomes in cancer treatment.
  • This advanced drug delivery system holds potential for future cancer cures.