Related Experiment Video
Updated: Feb 23, 2026

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis
Published on: April 25, 2025
Undiagnosed renal sarcoidosis in a patient with chronic interstitial nephritis
Wenfang Dong1,2, Bin Qiu3, Hongfeng Liu4
1Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Dongcheng district, ShuaiFu garden NO.1, Beijing, 100730, China.
Abstract:
A 53-year-old female was admitted to hospital, with acute elevation of SCr and hypercalcemia, on a 5-year history of chronic interstitial nephritis and stage III chronic kidney disease (CKD). Extensive workup failed to yield a definitive diagnosis concerning the cause of the disorder. Intense uptake of 18F-FDG in the spleen and liver was detected by PET/CT imaging with negative angiotensin-converting enzyme (ACE) in serum. The spleen and the hypermetabolism nodules of the liver were resected for histopathologic examination and turned out to be noncaseating granulomas, likely sarcoidosis. Combined with clinical features, the final diagnosis for this patient was sarcoidosis, involving the kidneys, spleen, liver, and lungs.
More Related Videos
Related Concept Videos
Nephrotic Syndrome II : Assessment and Medical Management
Nephrotic Syndrome I : Introduction
Chronic Kidney Disease III: Interprofessional Care
Acute Pyelonephritis II: Diagnostic Studies and Management
Acute Kidney Injury II: Pathophysiology
Chronic Kidney Disease II: Clinical Manifestations

