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Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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[Studies on flavonoids from Cirsium setosum].

Qin-Ge Ma1, Rong-Rui Wen2, Wen-Min Liu1

  • 1College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China.

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica
|September 7, 2017
PubMed
Summary
This summary is machine-generated.

Researchers isolated fifteen flavonoids from Cirsium setosum, identifying several with significant hypoglycemic activities. Compounds 2, 12, and 14 demonstrated potent inhibition of protein tyrosine phosphatase 1B (PTP1B), suggesting potential for diabetes treatment.

Keywords:
Cirsium setosumchemical constituentsflavonoidshypoglycemic activities

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Area of Science:

  • Natural Product Chemistry
  • Pharmacology
  • Medicinal Chemistry

Background:

  • Cirsium setosum is a plant with potential medicinal properties.
  • Flavonoids are a class of natural compounds known for diverse biological activities.
  • Protein tyrosine phosphatase 1B (PTP1B) is a key target for managing type 2 diabetes.

Purpose of the Study:

  • To isolate and identify chemical constituents from the ethyl acetate extract of Cirsium setosum.
  • To evaluate the hypoglycemic activities of the isolated compounds using a PTP1B enzyme inhibition model.

Main Methods:

  • Extraction of ethyl acetate from Cirsium setosum.
  • Isolation of compounds using column chromatography (silica gel, MCI, Sephadex LH-20) and preparative High-Performance Liquid Chromatography (HPLC).
  • Structure elucidation using spectroscopic data analysis and evaluation of PTP1B inhibitory activity.

Main Results:

  • Fifteen flavonoids were successfully isolated and identified, with all being reported from this plant for the first time.
  • Compounds 2 (4',5-dihydroxy-7,8-dimethoxyflavone), 12 (3'-hydroxy-4',5,7-trimethoxyflavone), and 14 (4',5-dihydroxy-2',3',7,8-tetramethoxylflavone) exhibited significant PTP1B inhibitory activities.
  • The IC₅₀ values for compounds 2, 12, and 14 were 2.54, 1.85, and 2.11 μmol•L⁻¹, respectively.

Conclusions:

  • The study successfully identified novel flavonoids from Cirsium setosum.
  • Specific flavonoids, particularly compounds 2, 12, and 14, show promising PTP1B inhibitory effects.
  • These findings suggest Cirsium setosum flavonoids may hold therapeutic potential for diabetes management.