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Published on: August 23, 2019
FKBP5 methylation as a possible marker for cortisol state and transient cortisol exposure in healthy human subjects
Britta K Winkler1, Hendrik Lehnert1, Henrik Oster1
1Department of Internal Medicine I, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany.
Abstract:
Current glucocorticoid replacement regimens, in adrenal insufficiency, fail to mimic the physiological cortisol secretion, thereby fostering serious side effects.
Aim:
To experimentally evaluate the impact of CpG methylation within the FKBP5 gene as a possible short- and long-term marker for cortisol exposure in humans.
Materials & Methods:
An ACTH-stimulation test was carried out and methylation status of the FKBP5 gene in leukocytes was determined.
Results:
A negative correlation between basal levels of methylation and serum cortisol was observed. Individual changes in FKBP5 methylation after 24 h correlated with cortisol responses.
Conclusion:
Considering previous studies conducted with murine leucocytes, FKBP5 methylation may be suitable as a long-term biomarker, rather than acute glucocorticoid exposure, also in humans.
