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Urinary Biomarkers for Chronic Kidney Disease with a Focus on Gene Transcript
Lin-Li Lyu1, Ye Feng1, Bi-Cheng Liu1
1Department of Nephrology, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, Jiangsu 210009, China.
Chinese Medical Journal
|September 7, 2017
Summary
Early detection of chronic kidney disease (CKD) relies on noninvasive biomarkers. Urine, particularly extracellular vesicles containing microRNA (miRNA) and messenger RNA (mRNA), shows promise for diagnosing CKD.
Area of Science:
- Nephrology
- Biomarker Discovery
- Precision Medicine
Background:
- Chronic kidney disease (CKD) management faces challenges in early, noninvasive biomarker detection.
- Urine offers a rich source of biological information for identifying noninvasive CKD biomarkers.
- Precision medicine necessitates advancements in early diagnostic tools for CKD.
Purpose of the Study:
- To review recent advancements in urinary biomarkers for chronic kidney disease (CKD).
- To explore the potential of different urine fractions for biomarker discovery.
- To highlight promising urinary biomarkers for CKD diagnosis and management.
Main Methods:
- Systematic review of PubMed database articles up to June 20, 2017.
- Keywords used: 'Chronic kidney disease', 'Biomarker', 'Urine'.
- Selection of original articles and key reviews on urinary biomarkers for CKD.
Main Results:
- Urinary biomarker studies focus on urine sediment, supernatant, and extracellular vesicles.
- Gene transcripts, including microRNA (miRNA) and messenger RNA (mRNA), demonstrate diagnostic potential for CKD.
- These biomarkers reflect kidney function and histological changes.
Conclusions:
- Various urine fractions hold significant potential for biomarker discovery.
- Urine extracellular vesicle mRNA and miRNA are identified as promising biomarkers for CKD.
- Further research is needed to address technical and data analysis challenges for clinical translation.
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