2017 publication guidelines for structural modelling of small-angle scattering data from biomolecules in solution: an...

Area of Science:

• Structural Biology
• Biophysics
• Biochemistry

Background:

• Preliminary guidelines for biomolecular small-angle scattering (SAS) were established in 2012.
• Biomolecular SAS has seen significant growth, with increasing adoption of these guidelines.
• Integrative/hybrid structural determination is a rapidly expanding field in structural biology.

Purpose of the Study:

• To update and refine guidelines for presenting biomolecular small-angle scattering (SAS) data in publications.
• To recommend the deposition of SAS data and models into public archives.
• To ensure open access for evaluating the quality and validity of SAS experiments and derived models.

Main Methods:

• Review and update of preliminary guidelines for biomolecular small-angle scattering (SAS).
• Consultation with international commissions and expert task forces.
• Recommendation for public data and model deposition.

Main Results:

• Updated guidelines for sample quality, data acquisition, reduction, presentation, validation, and modeling in SAS.
• Emphasis on open access to information for evaluating SAS data and models.
• Recommendation for deposition in public archives.

Conclusions:

• Updated guidelines will enhance the contribution of SAS to integrative structural biology.
• Open access to data and models is crucial for robust structural biology research.
• Adherence to updated guidelines and data deposition will improve the reliability and accessibility of biomolecular structures determined by SAS.