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A Web Application to Facilitate Syphilis Reactor Grid Evaluations.

Tigran Avoundjian, Christine M Khosropour, Matthew R Golden

    Sexually Transmitted Diseases
    |September 7, 2017
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    Summary
    This summary is machine-generated.

    A new web tool, the Syphilis Reactor Grid Evaluator (SRGE), helps health departments optimize syphilis testing protocols. Evaluating King County data showed potential efficiency gains of up to 25% with minimal impact on case finding.

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    Area of Science:

    • Public Health
    • Epidemiology
    • Infectious Disease Surveillance

    Background:

    • Health departments utilize

    Purpose of the Study:

    • To develop and evaluate a web-based tool, the Syphilis Reactor Grid Evaluator (SRGE), for optimizing syphilis serologic test result investigation protocols.
    • To assess the potential impact of modifying reactor grid algorithms on public health laboratory efficiency and case finding in King County, Washington.

    Main Methods:

    • Developed SRGE using R Shiny, incorporating syphilis titer results and disposition codes.
    • SRGE dynamically computes efficiency gains and case-finding loss based on user-defined investigation algorithms.
    • Compared the existing Public Health-Seattle & King County (PHSKC) reactor grid with five alternative algorithms using historical data.

    Main Results:

    • Analysis of 13,504 rapid plasma reagin results (2006-2015) linked 1565 to early syphilis cases.
    • Updating the PHSKC reactor grid could yield efficiency gains of 4.8%-25.2% (653-3403 reports).
    • Potential case-finding loss ranged from 1%-8.4% (10-99 fewer cases investigated).

    Conclusions:

    • The Syphilis Reactor Grid Evaluator (SRGE) enables rapid assessment of alternative reactor grid strategies.
    • Optimizing the reactor grid in King County can enhance efficiency with minimal compromise to syphilis case detection.