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Pre- and Postnatal Lung Development: An Updated Species Comparison
1Lewin ToxConsulting, Hannover, Germany.
Insights
This review outlines respiratory tract development, focusing on perinatal and postnatal maturation. It compares human development to animal models for pediatric pharmaceutical research and disease testing.
Area of Science:
- Developmental Biology
- Pediatric Pharmacology
- Respiratory Medicine
Background:
- Understanding lung development is crucial for addressing pediatric respiratory diseases.
- There is a growing need for robust data to support pediatric drug development.
- Existing models may not fully capture human respiratory tract maturation.
Purpose of the Study:
- To provide an overview of respiratory tract morphological and functional development.
- To emphasize perinatal and postnatal maturational processes.
- To compare human development with experimental animal models for pharmaceutical and disease research.
Main Methods:
- Literature review focusing on developmental biology and respiratory physiology.
- Comparative analysis of human and animal models of respiratory tract development.
- Synthesis of functional data relevant to pediatric airway diseases.
Main Results:
- Detailed description of morphological and functional changes during respiratory tract maturation.
- Identification of key differences and similarities between human and animal models.
- Presentation of functional data and models applicable to human airway diseases.
Conclusions:
- Accurate models are essential for advancing pediatric pharmaceutical development.
- Further research comparing human and animal respiratory development is warranted.
- This review provides a foundation for future studies in pediatric respiratory medicine.
Abstract:
The purpose of this review is to give an outline of respiratory tract morphological and functional development with an emphasis on perinatal and postnatal maturational processes. In view of the rising need for qualitative and quantitative data for the development of pediatric pharmaceuticals, a comparison of the human situation to experimental animal models is made, and functional data as well as suitable models for human airway diseases and functional testing are presented. Birth Defects Research 109:1519-1539, 2017. © 2017 Wiley Periodicals, Inc.
