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Related Experiment Video

Updated: Feb 23, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
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Corneal Collagen Cross-Linking Complications.

Charisma B Evangelista1, Kathryn M Hatch2

  • 1b Assistant Professor of Ophthalmology, Harvard Medical School, Cornea and Refractive Surgery Service , Massachusetts Eye and Ear , Waltham , MA , USA.

Seminars in Ophthalmology
|September 7, 2017
PubMed
Summary

Corneal cross-linking, approved in 2016, is increasingly used for keratoconus and post-LASIK ectasia. This review details potential complications associated with this vision-saving procedure.

Keywords:
Ectasiaepi-offepi-onkeratoconus (KCN)post-LASIK ectasiatransepithelial cross-linking (TE CXL)

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Area of Science:

  • Ophthalmology
  • Corneal Surgery

Background:

  • Corneal cross-linking (CXL) gained FDA approval in April 2016 for progressive keratoconus.
  • The use of CXL is expanding for treating keratoconus and post-LASIK ectasia.

Purpose of the Study:

  • To review reported complications of corneal collagen cross-linking.
  • Focus on complications in the context of keratoconus and post-LASIK ectasia treatment.

Main Methods:

  • Literature review of reported complications.
  • Analysis of studies concerning corneal cross-linking procedures.

Main Results:

  • Complications associated with CXL are becoming more recognized.
  • This review synthesizes known risks for clinicians and patients.

Conclusions:

  • Understanding CXL complications is crucial as its use increases.
  • This review provides a comprehensive overview of potential adverse events.