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Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice.

John C Newman1, Anthony J Covarrubias2, Minghao Zhao3

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|September 7, 2017
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Summary
This summary is machine-generated.

A cyclic ketogenic diet (KD) in mice reduced midlife mortality and improved memory and healthspan in old age. This non-obesogenic diet promotes longevity by altering metabolic pathways.

Keywords:
beta-hydroxybutyratehealthspanketogenic dietlongevity

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Area of Science:

  • Gerontology
  • Metabolic research
  • Nutritional science

Background:

  • Ketogenic diets mimic dietary restriction's metabolic effects, including fatty acid metabolism and ketone body production.
  • Investigating ketogenic diets' impact on longevity and healthspan is crucial for aging research.

Purpose of the Study:

  • To determine if an isoprotein ketogenic diet (KD) affects longevity and healthspan in aging C57BL/6 male mice.
  • To explore the mechanisms underlying the effects of KD on aging.

Main Methods:

  • Mice were fed a cyclic ketogenic diet (KD) alternated weekly with a control diet to prevent obesity.
  • A non-ketogenic high-fat diet (HF) was used for comparison.
  • Gene expression analysis was performed to identify molecular mechanisms.

Main Results:

  • Cyclic KD reduced midlife mortality but did not affect maximum lifespan.
  • KD improved memory performance and modestly improved composite healthspan measures in old mice.
  • Gene expression analysis revealed downregulation of insulin, protein synthesis, and fatty acid synthesis pathways, with unique upregulation of PPARα target genes in KD.

Conclusions:

  • A non-obesogenic cyclic ketogenic diet enhances survival, memory, and healthspan in aging mice.
  • The findings suggest KD as a potential intervention for promoting healthy aging.