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Related Experiment Video

Updated: Feb 23, 2026

Refined Murine Model of Idiopathic Pulmonary Fibrosis

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Published on: June 17, 2025

The lung in amyloidosis.

Paolo Milani¹, Marco Basset¹, Francesca Russo¹

¹Amyloidosis Research and Treatment Centre, Foundation IRCCS Policlinico San Matteo and Dept of Molecular Medicine, University of Pavia, Pavia, Italy.

European Respiratory Review : an Official Journal of the European Respiratory Society

|September 8, 2017

Summary

This summary is machine-generated.

Pulmonary amyloidosis involves protein misfolding and deposition in the lungs, potentially impairing respiratory function. Treatment depends on the amyloid type, with localized forms often having excellent prognoses.

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Area of Science:

Pulmonary Medicine
Pathology

Background:

Amyloidosis is characterized by misfolded protein deposition, leading to organ dysfunction.
Pulmonary amyloidosis can be localized or systemic, affecting respiratory health.
Symptoms arise when amyloid deposits severely impact lung structure and gas exchange.

Purpose of the Study:

To review the different types of pulmonary amyloidosis.
To outline diagnostic considerations and treatment strategies.

Main Methods:

Review of existing literature on pulmonary amyloidosis.
Classification based on location and clinical presentation.

Main Results:

Pulmonary interstitial amyloidosis causes respiratory impairment.
Nodular pulmonary amyloidosis is often localized and curable with excision.
Tracheobronchial amyloidosis may cause airway stenosis and is managed with bronchoscopy or radiation.

Conclusions:

Accurate determination of amyloid protein type is crucial for treatment selection.
Localized nodular pulmonary amyloidosis has an excellent prognosis.
Tracheobronchial amyloidosis requires specific interventions for airway stenosis.