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Updated: Feb 23, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Putative contact ketoconazole shampoo-triggered pemphigus foliaceus in a dog
Hyun-Jeong Sung1, In-Hwa Yoon1, Jung-Hyun Kim1
1Department of Veterinary Internal Medicine, Konkuk University Veterinary Medical Teaching Hospital, #120 Neungdong-ro, Gwangjin-gu, Seoul, 143-701, South Korea.
Abstract:
A 10-year-old spayed female cocker spaniel dog was referred for an evaluation of acute-onset generalized pustular cutaneous lesions following application of ketoconazole shampoo. Cytologic and histopathologic examinations of the lesions revealed intra-epidermal pustules with predominantly neutrophils and acantholytic cells. This is the first description of putative contact ketoconazole shampoo-triggered pemphigus foliaceus in a dog.
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