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Related Experiment Video

Updated: Feb 23, 2026

The Hypoxic Ischemic Encephalopathy Model of Perinatal Ischemia
08:47

The Hypoxic Ischemic Encephalopathy Model of Perinatal Ischemia

Published on: November 19, 2008

36.4K

Cell Death in the Developing Brain after Hypoxia-Ischemia.

Claire Thornton1, Bryan Leaw2, Carina Mallard3

  • 1Division of Imaging Sciences and Biomedical Engineering, Centre for the Developing Brain, King's College London, King's Health Partners, St. Thomas' HospitalLondon, United Kingdom.

Frontiers in Cellular Neuroscience
|September 8, 2017
PubMed
Summary

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Developing brains have unique cell death pathways after injury. Understanding these regulated and accidental cell death mechanisms is crucial for creating new neuroprotective therapies for conditions like hypoxia-ischemia.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Perinatal insults, such as hypoxia-ischemia, can cause secondary brain injury.
  • Cell death mechanisms in the developing brain differ significantly from those in adult brains.

Purpose of the Study:

  • To review and update knowledge on cell death mechanisms operating in the developing central nervous system (CNS).
  • To inform the development of novel neuroprotective therapies.

Main Methods:

  • Literature review focusing on cell death pathways in the developing CNS.
  • Analysis of molecular mechanisms underlying different cell death modalities.

Main Results:

  • Mild stress activates compensatory survival mechanisms.
Keywords:
apoptosishypoxia-ischemiamitochondrianecroptosisnecrosisperinatal brain injury

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Last Updated: Feb 23, 2026

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  • Moderate-to-severe insults trigger various regulated cell death pathways, including apoptosis, necroptosis, necrosis, autophagic cell death, and parthanatos.
  • Severe insults can lead to unmodifiable accidental cell death, releasing damage-associated molecular patterns that promote inflammation and secondary injury.

    • Conclusions:

    • The developing CNS employs diverse, context-dependent cell death pathways.
    • Inhibiting one cell death pathway may lead to compensatory activation of others.
    • Targeting these specific pathways is essential for developing effective neuroprotective strategies.