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Draft genome sequences of two opportunistic pathogenic strains of Staphylococcus cohnii isolated from human patients

Soraya Mendoza-Olazarán1, José F Garcia-Mazcorro2, Rayo Morfín-Otero3

  • 1Servicio de Gastroenterología, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León Mexico.

Standards in Genomic Sciences
|September 8, 2017
PubMed

Insights

Genome sequencing of two opportunistic Staphylococcus cohnii strains reveals new Staphylococcal Cassette Chromosome mec. These findings shed light on antibiotic resistance in human infections.

Area of Science:

  • Microbiology
  • Genomics
  • Infectious Diseases

Background:

  • Staphylococcus cohnii is an opportunistic pathogen.
  • Understanding its genome is crucial for combating infections.

Observation:

  • Two S. cohnii strains (SC-57, SC-532) were isolated from human blood and catheter samples.
  • Both strains exhibited low biofilm production and increased antibiotic resistance linked to biofilms.

Findings:

  • Draft genome sequences and annotations for both S. cohnii strains were generated.
  • Genes involved in metabolism (42%) and virulence (4%) were identified.
  • A novel Staphylococcal Cassette Chromosome mec (SCCmec class A, ccr type 1) was detected in both isolates.

Implications:

  • This study provides the first whole genome sequences of opportunistic S. cohnii from human patients.
  • The findings contribute to understanding the genetic basis of S. cohnii pathogenicity and antibiotic resistance.
  • Insights into SCCmec elements can inform strategies against Staphylococcal infections.
Keywords:
BiofilmClinical strainsCoagulase-negative staphylococciSCCmecShort genome reportStaphylococcus cohnii

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