Related Experiment Video
Updated: Feb 23, 2026
12:04
The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
Published on: November 1, 2015
18.8K
Pristane-induced lupus: considerations on this experimental model
Eduarda Correa Freitas1, Mayara Souza de Oliveira1, Odirlei André Monticielo2
1Laboratory of Autoimmune Diseases, Division of Rheumatology, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2350, room 645, Porto Alegre, 90035-003, Brazil.
Clinical Rheumatology
|September 8, 2017
Summary
The pristane-induced lupus (PIL) model aids understanding of systemic lupus erythematosus (SLE) pathogenesis. This model helps evaluate environmental factors and interferon signatures in SLE patients.
Area of Science:
- Immunology
- Autoimmunity
- Rheumatology
Background:
- Systemic lupus erythematosus (SLE) is a complex autoimmune disease.
- Genetic susceptibility and environmental factors contribute to SLE pathogenesis.
- Dysfunctional B and T lymphocyte responses drive autoantigen recognition and tissue damage.
Purpose of the Study:
- To review insights gained from the pristane-induced lupus (PIL) model.
- To explore the PIL model's utility in understanding SLE pathogenesis.
- To discuss current and future SLE therapies.
Main Methods:
- Literature search of PubMed, SciELO, and Embase databases (1950–2016).
- Focus on studies utilizing the pristane-induced lupus (PIL) murine model.
- Review of research on SLE pathogenesis, environmental factors, and therapies.
Main Results:
- The PIL model provides valuable insights into systemic autoimmunity mechanisms.
- PIL is effective for studying environmental influences on SLE.
- The model aids in understanding interferon signatures in SLE patients.
Conclusions:
- The PIL model is a crucial tool for advancing SLE research.
- Understanding SLE pathogenesis is enhanced through murine models.
- The PIL model can guide the development of novel SLE therapies.
