Related Experiment Video
Updated: Feb 23, 2026
08:14
A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model
Published on: February 28, 2018
9.4K
Colonic Spirochetes: What Has Genomics Taught Us?
David John Hampson1, Penghao Wang2
1School of Veterinary and Life Sciences, Murdoch University, Perth, WA, 6150, Australia. d.hampson@murdoch.edu.au.
Current Topics in Microbiology and Immunology
|September 8, 2017
Summary
Brachyspira bacteria, or spirochetes, colonize animal intestines. Comparative genomics of 56 strains reveals gene rearrangements and drug resistance, improving understanding of these bacteria.
Area of Science:
- Microbiology
- Genomics
- Bacterial Pathogenesis
Background:
- Brachyspira are anaerobic, 'colonic' spirochetes with limited study in physiology and molecular biology.
- Pathogenic and non-pathogenic species colonize the large intestines of various animals and birds.
- Genomic data availability has increased significantly since 2009, with representatives of all nine species sequenced.
Purpose of the Study:
- To summarize current knowledge on Brachyspira spp.
- To present a preliminary comparative genomic analysis of 56 Brachyspira strains.
- To investigate gene island rearrangements, phenotypes, and mutation mechanisms.
Main Methods:
- Comparative genomic analysis of 56 Brachyspira strains.
- Utilizing publicly available genome sequences.
- Application of Next-Generation Sequencing (NGS) data.
Main Results:
- Detailed genetic maps of Brachyspira species were generated.
- Gene island rearrangements and putative phenotypes, including antimicrobial drug resistance, were identified.
- Mechanisms enabling bacterial evolution and stress response were elucidated.
Conclusions:
- Comparative genomics provides insights into Brachyspira evolution and adaptation.
- Further genomic studies using NGS will enhance understanding of these spirochetes.
- Findings contribute to the study of bacterial pathogenesis and antimicrobial resistance.
More Related Videos
09:44Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing
Published on: December 23, 2022
3.0K
09:49Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection
Published on: November 18, 2022
2.9K
Related Concept Videos
01:30Bacterial Phylum Spirochaetes
948
Spirochetes, unique bacteria in the phylum Spirochaetes, are gram-negative, motile, tightly coiled, slender, and flexible. They inhabit aquatic sediments and animals, with some causing diseases like syphilis. Spirochetes are classified into eight genera based on habitat, pathogenicity, phylogeny, and characteristics.Their distinctive motility arises from endoflagella, located within the cell’s periplasm. These endoflagella anchor at the cell poles and extend along the cell length, encased...
948
01:29Modern Molecular Taxonomy
759
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
759
01:29Bacterial Flora of the Large Intestine
1.8K
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
1.8K
00:46Genomic DNA in Prokaryotes
49.1K
The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...
Genomic Diversity in Bacteria
Although bacterial genomes are much...
49.1K
01:20Applications of Molecular Taxonomy
614
Molecular taxonomy has revolutionized the understanding and classification of bacteria, providing precise insights into their diversity, evolutionary relationships, and ecological roles. By utilizing molecular techniques such as DNA sequencing and fingerprinting, researchers have made significant strides in various fields related to bacterial studies.Resolving Taxonomic AmbiguitiesMolecular taxonomy has been instrumental in distinguishing closely related bacterial species initially thought to...
614
02:02Genomics
41.0K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
41.0K