Lung Squamous Cell Carcinoma with De Novo c-Met Amplification

The study presented a case of lung squamous cell carcinoma (SCC) with de novo c-Met amplification. Four cycles of neoadjuvant chemotherapy were administered and partial response was achieved. Surgery was performed and the surgical margin was positive. Pathological diagnosis was lung SCC with c-ros oncogene 1 (ROS1) (+, 5%) and c-Met (++, 20%). The ROS1 rearrangement and c-Met amplification were detected using fluorescence in situ hybridization, and the result showed c-Met amplification positive and ROS1 negative. Four weeks after surgery, thoracic computed tomography scan showed a relapse of hilar and mediastinal lymph nodes. After three days, the patient died of hemoptysis.