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Ethical Issues Regarding CRISPR Mediated Genome Editing.

Zabta Khan Shinwari1, Faouzia Tanveer2, Ali Talha Khalil2

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CRISPR-Cas9 gene editing offers rapid advancements but raises ethical concerns, especially for human germline modifications. Responsible use requires global dialogue and strict regulations for future clinical applications.

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Area of Science:

  • Molecular Biology
  • Biotechnology
  • Bioethics

Background:

  • CRISPR-Cas9 is a revolutionary genome editing technology transforming molecular biology.
  • Its applications span agriculture, environment, and clinical therapeutics.
  • Significant ethical, moral, and safety concerns accompany its widespread use.

Purpose of the Study:

  • To highlight the transformative potential of CRISPR-Cas9 technology.
  • To address the ethical, moral, and safety concerns associated with its applications, particularly human germline modifications.
  • To emphasize the need for global dialogue and stringent regulations for responsible implementation.

Main Methods:

  • Review of current literature on CRISPR-Cas9 applications and ethical considerations.
  • Analysis of contentious issues in human germline modification, including safety, consent, and eugenics.
  • Discussion on the necessity of regulatory frameworks and societal engagement.

Main Results:

  • CRISPR-Cas9 presents immense potential but poses risks of unforeseen effects in clinical settings.
  • Human germline modification raises profound ethical questions regarding safety, informed consent, and potential for eugenics.
  • A broad societal dialogue involving scientists, ethicists, policymakers, and the public is crucial.

Conclusions:

  • Responsible innovation in CRISPR-Cas9 necessitates stringent regulations and ethical guidelines.
  • Ongoing global debate and public engagement are vital for navigating the societal implications of genome editing.
  • While research may proceed under existing frameworks, future clinical applications require newly established, strict regulations.