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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

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[Periodical medication review: bigger and better?]

R J van Marum¹

¹Jeroen Bosch Ziekenhuis, afd. geriatrie, 's-Hertogenbosch en VUmc, afd. Huisartsgeneeskunde en Ouderengeneeskunde, Amsterdam.

Nederlands Tijdschrift Voor Geneeskunde

|September 8, 2017

Summary

Periodic medication reviews for older adults lack strong evidence for broad application. Focusing reviews on high-risk patients may be more cost-effective than widespread implementation.

Area of Science:

Geriatrics
Pharmacology
Health Services Research

Background:

The Netherlands' 2012 practice guideline suggested selecting older adults for periodic medication reviews.
The guideline committee acknowledged a lack of firm evidence supporting patient selection criteria.
Recent studies have not demonstrated significant patient-related benefits from medication reviews.

Purpose of the Study:

To evaluate the effectiveness and cost-effectiveness of medication reviews in older populations.
To determine optimal patient selection strategies for medication review interventions.

Main Methods:

Review of existing literature and guideline recommendations on polypharmacy management in older adults.
Analysis of recent studies assessing the impact of medication reviews on patient outcomes.

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Main Results:

Evidence supporting the selection of patients for medication review remains limited.
Recent evaluations show minimal positive effects of medication reviews on patient-related outcomes.
Regulatory bodies suggest expanding the target population for medication reviews.

Conclusions:

Widespread implementation of medication reviews for all older people may not be cost-effective.
A more selective approach, targeting patients most likely to benefit, is recommended.
Further research is needed to identify specific patient subgroups that benefit most from medication reviews.