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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Tissue Transplantation01:24

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Measurement of T Cell Alloreactivity Using Imaging Flow Cytometry
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Biomarkers in solid organ transplantation.

Teun van Gelder1,2

  • 1Department of Hospital Pharmacy, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.

British Journal of Clinical Pharmacology
|September 8, 2017
PubMed
Summary
This summary is machine-generated.

Personalized medicine is lacking for organ transplant recipients. Biomarkers could help tailor immunosuppressive treatments by monitoring immune status or early organ damage.

Keywords:
biomarkersimmunosuppressionrejectiontransplantation

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Area of Science:

  • Immunology
  • Transplantation Medicine
  • Biomarker Discovery

Background:

  • Solid organ transplantation (kidney, heart) relies on standard immunosuppression.
  • Personalized medicine approaches are not yet standard clinical practice for these patients.
  • Current treatments lack individual patient-specific adjustments.

Purpose of the Study:

  • To explore the potential of biomarkers in tailoring immunosuppressive therapy for organ transplant recipients.
  • To identify biomarkers that can reflect individual immune status.
  • To identify biomarkers that can indicate early damage to the transplanted organ.

Main Methods:

  • The study reviews current literature on immunosuppression and biomarker research in transplantation.
  • Analysis of existing data on immune monitoring and organ damage markers.
  • Exploration of potential biomarker candidates for clinical application.

Main Results:

  • Biomarkers hold promise for personalizing immunosuppressive drug dosages.
  • Potential biomarkers can indicate the level of immune suppression.
  • Biomarkers may detect subclinical or early signs of organ injury.
  • This could lead to proactive treatment adjustments.

Conclusions:

  • Biomarker development is crucial for advancing personalized medicine in organ transplantation.
  • Tailored immunosuppression based on biomarkers can optimize patient outcomes.
  • Future research should focus on validating and implementing these biomarkers in clinical settings.