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Innate lymphoid cells at the interface between obesity and asthma
Laetitia Everaere1,2,3,4, Saliha Ait Yahia1,2,3,4, Mélodie Bouté1,2,3,4
1Institut National de la Santé et de la Recherche Médicale, Lille, France.
Immunology
|September 8, 2017
Summary
Innate lymphoid cells (ILCs) link obesity and asthma. Group 2 ILCs (ILC2) benefit obesity but worsen asthma, despite their shared prevalence.
Area of Science:
- Immunology
- Respiratory Medicine
- Metabolic Disorders
Background:
- Obesity and asthma prevalence have risen concurrently.
- Obesity is a significant risk factor for asthma, yet mechanisms are unclear.
- Innate lymphoid cells (ILCs) are implicated in both conditions.
Purpose of the Study:
- To review the roles of ILCs in obesity and asthma.
- To explore ILCs as a potential link between these diseases.
- To examine the paradoxical roles of group 2 ILCs (ILC2).
Main Methods:
- Review of epidemiological studies and immunological data.
- Analysis of ILC function in adipose and lung tissues.
- Investigation of cytokine signaling pathways (IL-33, IL-25).
Main Results:
- ILCs, particularly ILC2, are found in relevant tissues.
- ILC2 activation is linked to IL-33 and IL-25.
- ILC2 are beneficial in obesity but detrimental in asthma.
Conclusions:
- ILCs represent a potential mechanistic link between obesity and asthma.
- The distinct roles of ILC2 in each disease warrant further investigation.
- Understanding ILC function may offer novel therapeutic targets.
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