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Xk-related protein 8 regulates myoblast differentiation and survival

Go-Woon Kim1, Gi-Hoon Nam1,2, In-San Kim1,2

  • 1Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul, Korea.

The FEBS Journal
|September 8, 2017
PubMed

Insights

Xk-related protein 8 (Xkr8) promotes muscle cell (myoblast) differentiation and survival. This protein enhances myotube formation and protects cells during differentiation, indicating its crucial role in myogenesis.

Area of Science:

  • Cell Biology
  • Muscle Development

Background:

  • Phosphatidylserine (PS) exposure is critical for myotube formation during myoblast differentiation.
  • The specific role of Xk-related protein 8 (Xkr8), a PS scramblase, in myogenesis remained unclear.

Discussion:

  • Xkr8 overexpression accelerates myoblast differentiation and promotes the formation of larger myotubes.
  • This pro-myogenic effect of Xkr8 is independent of caspase-dependent cleavage.
  • Xkr8 enhances cell-death resistance in differentiated myoblasts.

Key Insights:

  • Xkr8 acts as a positive regulator in terminal differentiation and myoblast survival.
  • Xkr8 knockdown impairs myoblast differentiation and increases apoptosis during differentiation.
  • Xkr8 influences myoblast proliferation and survival, impacting overall myogenesis.

Outlook:

  • Further research into Xkr8's non-caspase-dependent functions in myogenesis.
  • Investigating Xkr8's potential as a therapeutic target for muscle-related disorders.
  • Elucidating the precise molecular mechanisms by which Xkr8 regulates myoblast survival and proliferation.
Keywords:
Xk-related protein 8apoptosisdifferentiationmyoblastsscramblase

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