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Associations between LMO1 gene polymorphisms and Wilms' tumor susceptibility
Guo-Chang Liu1, Zhen-Jian Zhuo2, Shi-Bo Zhu1
1Department of Pediatric Urology, Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China.
Oncotarget
|September 9, 2017
Summary
Genetic variations in the LIM domain only 1 (LMO1) gene are associated with childhood Wilms' tumor risk. Specific LMO1 polymorphisms, particularly rs110419, show a protective effect, especially in males, warranting further investigation.
Area of Science:
- Genetics
- Pediatric Oncology
- Molecular Biology
Background:
- Wilms' tumor is the most common kidney cancer in children.
- Genome-wide association studies have implicated the LIM domain only 1 (LMO1) gene in oncogenesis.
Purpose of the Study:
- To investigate the association between LMO1 gene polymorphisms and Wilms' tumor susceptibility.
- To identify specific LMO1 variants that may influence Wilms' tumor risk.
Main Methods:
- A hospital-based case-control study involving 145 Wilms' tumor patients and 531 cancer-free children.
- Genotyping of four LMO1 polymorphisms (rs110419, rs4758051, rs10840002, rs204938) using Taqman methodology.
- Statistical analysis using odds ratios (ORs) and 95% confidence intervals (CIs).
Main Results:
- The rs110419 AG polymorphism demonstrated a protective effect against Wilms' tumor (adjusted OR = 0.62).
- Carrying 1-4 risk genotypes significantly increased Wilms' tumor risk (adjusted OR = 1.84).
- The protective effect of rs110419 AG/GG was more pronounced in males, and risk genotype associations were observed in older children (>18 months), females, and those in advanced stages (III+IV).
Conclusions:
- LMO1 gene polymorphisms may play a role in Wilms' tumor susceptibility.
- The findings suggest potential sex-specific and age-specific effects of LMO1 variants on Wilms' tumor risk.
- Further validation in larger, diverse populations is recommended.
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