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Updated: Feb 23, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

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Optimizing antimicrobial prescribing: a practical decalogue

E Moreno-García, J García Rodríguez, J R Paño-Pardo1

  • 1José Ramón Paño-Pardo, Servicio de Enfermedades Infecciosas. Hospital Clínico Universitario "Lozano Blesa" Avenida San Juan Bosco 15. 50009 Zaragoza, Spain. jrpanno@salud.aragon.es.

Revista Espanola De Quimioterapia : Publicacion Oficial De La Sociedad Espanola De Quimioterapia
|September 9, 2017
PubMed

Insights

Antibiotic resistance is a major global health threat due to slowed drug development. Improving antimicrobial prescribing is crucial for patient outcomes and controlling resistance, with key strategies outlined.

Area of Science:

  • Public Health
  • Infectious Diseases
  • Pharmacology

Background:

  • Antibiotic resistance poses a significant global challenge, exacerbated by a slowdown in new antimicrobial drug development over the past two decades.
  • Infections caused by antibiotic-resistant microorganisms lead to prolonged hospital stays, increased mortality rates, and higher healthcare costs.
  • The diminishing pipeline of antimicrobial agents necessitates a focus on optimizing the use of existing therapies.

Purpose of the Study:

  • To highlight the critical issue of rising antibiotic resistance worldwide.
  • To emphasize the importance of improving antimicrobial prescribing practices.
  • To provide actionable strategies for optimizing antimicrobial use in clinical settings.

Main Methods:

  • Review of current literature on antibiotic resistance trends.
  • Analysis of the impact of antibiotic resistance on patient outcomes and healthcare systems.
  • Development of a set of key messages for improving antimicrobial prescribing.

Main Results:

  • Antimicrobial drug development has significantly decelerated in the last 20 years.
  • Antibiotic-resistant infections are linked to adverse clinical and economic consequences.
  • Effective antimicrobial stewardship is a vital component in managing infections and combating resistance.

Conclusions:

  • Optimizing antimicrobial prescribing is an essential strategy to improve patient care for moderate to severe infections.
  • Implementing evidence-based prescribing practices can help mitigate the spread of antibiotic resistance.
  • A decalogue of key messages offers practical guidance for healthcare professionals to enhance antimicrobial stewardship.

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