Associations between dynamic functional connectivity and age, metabolic risk, and cognitive performance
Raymond P Viviano1, Naftali Raz1, Peng Yuan2
1Department of Psychology, Wayne State University, Detroit, MI, USA; Institute of Gerontology, Wayne State University, Detroit, MI, USA.
Neurobiology of Aging
|September 9, 2017
Summary
Aging affects brain connectivity dynamics. Dynamic functional connectivity analysis reveals age-related changes and links specific brain network patterns to metabolic risk and executive functions in healthy adults.
Area of Science:
- Neuroscience
- Cognitive Neuroscience
- Neuroimaging
Background:
- Advanced age is linked to decreased functional connectivity in brain networks, especially the default mode network.
- Previous research primarily used static functional connectivity measures, overlooking short-term temporal dynamics.
Purpose of the Study:
- To investigate age-related differences in dynamic functional connectivity.
- To explore associations between dynamic connectivity, metabolic risk, and cognitive performance in healthy adults.
Main Methods:
- Resting-state functional magnetic resonance imaging (fMRI) data from 168 healthy adults (aged 18-83).
- Sliding-window k-means clustering applied to assess dynamic functional connectivity.
- Analysis of associations between dynamic connectivity profiles, metabolic risk, and cognitive measures.
Main Results:
- Three of eight identified dynamic connectivity profiles showed significant associations with age.
- Metabolic risk correlated with the time spent in two specific dynamic connectivity profiles.
- Increased time in a profile with heightened default mode and medial temporal connectivity correlated positively with executive functions.
Conclusions:
- Dynamic functional connectivity analysis provides insights into aging brain processes beyond static measures.
- Age-related changes in brain network temporal dynamics are observable.
- Specific dynamic connectivity patterns are associated with metabolic health and cognitive abilities, particularly executive functions.
More Related Videos
10:13Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
Published on: February 14, 2014
14.3K
09:38Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
15.8K
Related Concept Videos
01:30Cognitive Development During Adulthood
962
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
962
01:26Aging
885
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
885
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
257
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
257
01:37Mitochondria
20.9K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
20.9K