Related Experiment Video

Updated: Feb 23, 2026

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
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Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade

Published on: March 14, 2011

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Successful management of a severe anti-M alloimmunization during pregnancy

Corinne Hubinont1, Gilda Delens1, Julie Vanalbada De Haan Hettema1

  • 1Division of Obstetrics, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain (UCL), B-1200 Bruxelles, Belgium.

European Journal of Obstetrics, Gynecology, and Reproductive Biology
|September 9, 2017
PubMed

We report the successful outcome of a patient with anti-M antibodies with a previous history of severe hemolysis of erythrocytes. Serial plasma exchange from the first trimester combined with ultrasound monitoring of the fetal middle cerebral artery blood velocity was implemented. This management allowed a favorable pregnancy outcome of an infant born by an elective caesarean section at 32 weeks 6/7 with a normal Apgar score at 8/9/10. The other therapeutic alternatives such as intravenous immunoglobulin and in utero fetal blood transfusions are discussed.

Keywords:
Anti-M antibodiesHemolytic disease of the fetus and newbornPlasmapheresis

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