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Folate and microRNA: Bidirectional interactions

Emma L Beckett1, Martin Veysey2, Mark Lucock3

  • 1School of Medicine and Public Health, The University of Newcastle, Australia.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|September 9, 2017
PubMed

Insights

Low folate status increases disease risk, with emerging evidence showing a bidirectional relationship between folate and microRNA (miRNA). Folate influences miRNA levels, while miRNAs regulate folate metabolism, impacting DNA methylation and cellular processes.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Nutritional Science

Background:

  • Low folate status is associated with increased risks of developmental disorders, cancers, neurodegenerative, and cardiovascular diseases.
  • Aberrant microRNA (miRNA) profiles are characteristic of these conditions, prompting investigation into the folate-miRNA relationship.

Purpose of the Study:

  • To investigate the bidirectional associations between folate status and microRNA (miRNA) profiles.
  • To explore the role of miRNAs in regulating folate-mediated one-carbon metabolism and vice versa.

Main Methods:

  • Review of emerging evidence linking folate levels to miRNA regulation.
  • Examination of miRNA's role in modulating enzymes of folate-mediated one-carbon metabolism.
  • Consideration of epigenetic mechanisms influencing miRNA expression and folate pathways.

Main Results:

  • Evidence suggests folate levels can modulate miRNA expression.
  • miRNAs are implicated in regulating enzymes crucial for one-carbon metabolism, including DNA methylation.
  • Potential bidirectional interactions between folate status and miRNA profiles are indicated.

Conclusions:

  • The interplay between folate status and miRNA profiles is complex and likely bidirectional.
  • miRNAs may serve as potential biomarkers for diagnosing or predicting conditions linked to folate status.
  • Understanding these interactions is crucial for elucidating disease mechanisms and developing therapeutic strategies.
Keywords:
CancerDevelopmentFolateFolic acidNeural tube defectsmicroRNA

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