Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

2.2K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
2.2K
Neural Regulation01:37

Neural Regulation

43.6K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
43.6K
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

1.8K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.8K
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

1.8K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Family-Based Preventive Interventions for Problematic Internet Use Among Children and Adolescents: Protocol for a Systematic Review and Meta-Analysis.

International journal of environmental research and public health·2026
Same author

Allergy-Aware Protocol for Blenderized Tube Feeding Initiation in Children With Severe Motor and Intellectual Disability.

Pediatrics international : official journal of the Japan Pediatric Society·2026
Same author

Low-Cost Community-Based Personal Alarm Intervention for Preventing Sexual Victimization in Indian Urban Slums: A Cluster Randomized Controlled Trial.

Journal of interpersonal violence·2026
Same author

The DOCK3-HAUS7 axis: A new paradigm in optic nerve regeneration.

Neural regeneration research·2026
Same author

Correlations between amyloid-β peptide levels in aqueous humor and retinal thickness in patients with glaucoma.

Scientific reports·2025
Same author

The thyroid hormone receptor beta (TR-β) signaling controls pathogenic Th17 cells in autoimmune disease.

International immunology·2025

Related Experiment Video

Updated: Feb 23, 2026

Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans
07:04

Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans

Published on: August 15, 2020

5.9K

ASK1 in neurodegeneration.

Xiaoli Guo1, Kazuhiko Namekata1, Atsuko Kimura1

  • 1Visual Research Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.

Advances in Biological Regulation
|September 9, 2017
PubMed
Summary

Oxidative stress activates apoptosis signal-regulating kinase 1 (ASK1), a key factor in neurodegenerative diseases (NDDs). Targeting ASK1 signaling offers a potential new therapeutic strategy for treating these debilitating conditions.

More Related Videos

Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein
14:45

Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein

Published on: July 29, 2022

6.7K
Modeling Neuronal Death and Degeneration in Mouse Primary Cerebellar Granule Neurons
10:36

Modeling Neuronal Death and Degeneration in Mouse Primary Cerebellar Granule Neurons

Published on: November 6, 2017

8.6K

Related Experiment Videos

Last Updated: Feb 23, 2026

Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans
07:04

Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans

Published on: August 15, 2020

5.9K
Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein
14:45

Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein

Published on: July 29, 2022

6.7K
Modeling Neuronal Death and Degeneration in Mouse Primary Cerebellar Granule Neurons
10:36

Modeling Neuronal Death and Degeneration in Mouse Primary Cerebellar Granule Neurons

Published on: November 6, 2017

8.6K

Area of Science:

  • Neuroscience
  • Cell Biology
  • Pathology

Background:

  • Neurodegenerative diseases (NDDs) like Alzheimer's and Parkinson's are increasing globally due to longer lifespans.
  • Oxidative stress, an imbalance between oxidants and antioxidants, is a critical factor in NDD pathogenesis.
  • Apoptosis signal-regulating kinase 1 (ASK1) is a molecule activated by oxidative stress and implicated in NDDs.

Purpose of the Study:

  • To review experimental evidence linking ASK1 signaling to the pathogenesis of various NDDs.
  • To explore ASK1 as a potential therapeutic target for NDDs.

Main Methods:

  • Review of experimental data connecting ASK1 signaling pathways to NDDs.
  • Analysis of ASK1 activation mechanisms under oxidative stress conditions.

Main Results:

  • Oxidative stress, via reactive oxygen species (ROS), triggers ASK1 activation through thioredoxin dissociation, oligomerization, and phosphorylation.
  • This ASK1 activation cascade leads to neuronal cell death, contributing to NDD progression.
  • Evidence links ASK1 signaling directly to the pathophysiology of multiple NDDs.

Conclusions:

  • ASK1 signaling is a significant contributor to the pathogenesis of several neurodegenerative diseases.
  • Modulating ASK1 activity presents a promising therapeutic avenue for preventing or treating NDDs.