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PEGylation for enhancing nanoparticle diffusion in mucus.

Justin T Huckaby1, Samuel K Lai2

  • 1UNC/NCSU Joint Department of Biomedical Engineering, University of North Carolina - Chapel Hill, 125 Mason Farm Road, Chapel Hill, NC 27599, USA.

Advanced Drug Delivery Reviews
|September 9, 2017
PubMed
Summary
This summary is machine-generated.

Polyethylene glycol (PEG) coatings enable nanoparticles to penetrate mucus, improving drug delivery to mucosal surfaces. This review details PEG-based mucus-penetrating particles for enhanced drug and gene delivery.

Keywords:
DiffusivityMuco-inertMucusMucus barrierMucus-penetratingNanoparticlePEG

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery

Background:

  • Viscoelastic mucus layers trap foreign particles and drug delivery systems, hindering effective treatment at mucosal surfaces.
  • Developing nanoparticles that can penetrate mucus is crucial for sustained and targeted drug delivery.
  • Polyethylene glycol (PEG) has emerged as a key material for engineering mucus-penetrating nanoparticles.

Purpose of the Study:

  • To review the historical development of PEG-based mucus-penetrating particles.
  • To highlight the physicochemical properties of PEG coatings that facilitate mucus penetration.
  • To discuss PEGylation strategies for optimizing nanoparticle drug carriers for mucosal delivery.

Main Methods:

  • Review of scientific literature on PEGylated nanoparticles for mucus penetration.
  • Analysis of physicochemical properties of PEG coatings (e.g., density, grafting density).
  • Examination of various PEGylation strategies and their impact on muco-inertness.

Main Results:

  • The first synthetic mucus-penetrating nanoparticles utilized dense polyethylene glycol (PEG) coatings.
  • PEGylation has become the standard for developing drug carriers for mucosal delivery across various organs.
  • Specific PEG coating properties and PEGylation techniques enhance particle distribution and epithelial targeting.

Conclusions:

  • PEG-based nanoparticles are highly effective for overcoming mucus barriers in drug and gene delivery.
  • Understanding PEG coating properties is essential for designing advanced muco-inert drug carriers.
  • This approach significantly improves drug and gene delivery efficiency at mucosal surfaces.