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Integrated results from the COPERNICUS and GALILEO studies
Amelie Pielen1,2, W Lloyd Clark3, David S Boyer4
1Eye Center, University Hospital Freiburg, Eye Hospital, Freiburg.
Clinical Ophthalmology (Auckland, N.Z.)
|September 9, 2017
Summary
Intravitreal aflibercept effectively treats macular edema from central retinal vein occlusion (CRVO). Patients receiving aflibercept showed greater visual and anatomic improvements compared to sham treatment in an integrated analysis.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Vascular Occlusions
Background:
- Macular edema secondary to central retinal vein occlusion (CRVO) causes significant vision loss.
- Intravitreal aflibercept is a potential therapeutic agent for CRVO-related macular edema.
Purpose of the Study:
- To evaluate the efficacy and safety of intravitreal aflibercept for treating macular edema in CRVO patients.
- To present an integrated analysis of the COPERNICUS and GALILEO clinical trials.
Main Methods:
- Randomized controlled trial design comparing intravitreal aflibercept (2 mg) to sham injections.
- Patients received 4-weekly injections initially, followed by an as-needed treatment phase.
- Integrated analysis of data from two independent studies, COPERNICUS and GALILEO.
Main Results:
- Intravitreal aflibercept demonstrated superior improvements in best-corrected visual acuity and central retinal thickness compared to sham at week 24.
- Continued aflibercept treatment (as-needed) maintained visual gains, while sham groups showed less improvement.
- Ocular serious adverse events were infrequent, occurring in less than 10% of patients.
Conclusions:
- Integrated data from COPERNICUS and GALILEO confirm intravitreal aflibercept as an effective treatment for CRVO-induced macular edema.
- The study supports the long-term efficacy and safety profile of intravitreal aflibercept in this patient population.
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