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Drug delivery approaches for breast cancer

Santosh Kumar Singh1, Shriti Singh2, James W Lillard1

  • 1Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA, USA.

International Journal of Nanomedicine
|September 9, 2017
PubMed

Insights

Nanoparticles enhance breast cancer therapy by enabling controlled drug release and improving drug stability. This nanotechnology approach offers a promising alternative to traditional chemotherapy, reducing toxicity and increasing treatment efficiency.

Area of Science:

  • Oncology
  • Nanomedicine
  • Drug Delivery Systems

Background:

  • Breast cancer is a leading global health concern for women.
  • Conventional chemotherapy faces challenges including systemic toxicity and limited efficacy.
  • Nanotechnology offers novel strategies to improve cancer treatment outcomes.

Purpose of the Study:

  • To review current challenges in breast cancer therapy.
  • To discuss nanoparticle-based drug delivery systems for improved breast cancer treatment.
  • To highlight receptor-based targeting as an emerging therapeutic strategy.

Main Methods:

  • Review of current literature on breast cancer treatment modalities.
  • Analysis of nanoparticle properties for drug delivery (loading capacity, stability, toxicity).
  • Exploration of receptor-based targeting mechanisms in cancer therapy.

Main Results:

  • Nanoparticle drug delivery systems show high loading capacity, enhanced stability, and reduced toxicity compared to traditional chemotherapeutics.
  • Nanotechnology aids in understanding cancer cell-microenvironment interactions.
  • Receptor-based targeting strategies are progressing in clinical trials.

Conclusions:

  • Nanoparticle-based drug delivery presents a significant advancement in overcoming limitations of conventional breast cancer therapies.
  • Targeted drug delivery using nanoparticles can improve therapeutic efficiency and patient outcomes.
  • Further research and clinical application of nanomedicine hold great promise for breast cancer management.
Keywords:
breast cancerdrug delivery systemsnanoparticles

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