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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

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Modalities of ventricular pacing for cardiac resynchronization therapy in patients with heart failure: a

Ailan Chen1, Xinyu Chen2, Yuechun Shen1

  • 1Department of Cardiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Archives of Medical Science : AMS
|September 9, 2017
PubMed

Insights

Triventricular cardiac resynchronization therapy (CRT) shows promise for heart failure patients, offering improved left ventricular ejection fraction (LVEF) compared to biventricular pacing. Further trials are needed to confirm these findings for CRT modalities.

Area of Science:

  • Cardiology
  • Medical Devices
  • Heart Failure Management

Background:

  • Cardiac resynchronization therapy (CRT) is used to manage heart failure.
  • Different CRT modalities exist, including biventricular (BiV), univentricular (LUV/RUV), and triventricular (TriV) pacing.
  • Comparative outcomes of these CRT modalities require thorough evaluation.

Purpose of the Study:

  • To compare clinical and functional outcomes of various cardiac resynchronization therapy (CRT) modalities.
  • To evaluate the effectiveness of different CRT pacing strategies in heart failure (HF) patients.

Main Methods:

  • A meta-analysis of 14 studies comparing CRT modalities was conducted.
  • Studies were identified through comprehensive database searches (Medline, PubMed, Cochrane, Google Scholar).
  • Clinical outcomes (peak O2 consumption, LVEF) and functional outcomes (6-min walk distance, quality of life) were analyzed.

Main Results:

  • No significant difference in 6-min walk distance was observed between BiV and univentricular (LUV/RUV) or triventricular (TriV) groups.
  • Peak oxygen consumption was comparable between BiV and LUV/RUV groups.
  • Triventricular (TriV) CRT demonstrated a significant improvement in left ventricular ejection fraction (LVEF) compared to biventricular (BiV) pacing.

Conclusions:

  • Triventricular (TriV) CRT presents a compelling alternative for heart failure management compared to univentricular or biventricular pacing.
  • Further large-scale randomized trials are essential to validate the observed benefits of TriV CRT.
Abstract

Keywords:
biventricularcardiac resynchronization therapyheart failureleft ventricular ejection fractiontriventricular

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