Related Experiment Video

Updated: Feb 23, 2026

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

1.6K

Plasma soluble CD36, carotid intima-media thickness and cognitive function in patients with type 2 diabetes

Xiaozhen Jiang1, Xiaohui Zhao2, Ruihua Chen1

  • 1Department of Endocrinology, Shanghai Pudong New Area People's Hospital, Shanghai, China.

Archives of Medical Science : AMS
|September 9, 2017
PubMed

Insights

In type 2 diabetes, soluble CD36 (sCD36) is linked to carotid intima-media thickness (IMT), a marker of atherosclerosis. While IMT correlates with cognitive function, sCD36 itself did not show a direct association with cognitive scores in this study.

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Neuroscience

Background:

  • Diabetes and atherosclerosis are established risk factors for cognitive deficits.
  • Scavenger receptor CD36 (sCD36) is implicated in diabetes and atherosclerosis, suggesting a potential role in cognitive impairment.

Purpose of the Study:

  • To investigate the relationship between plasma soluble CD36 (sCD36) levels and carotid intima-media thickness (IMT) in patients with type 2 diabetes.
  • To determine the association of sCD36 and IMT with cognitive function, assessed using the Montreal Cognitive Assessment (MoCA) scoring system.

Main Methods:

  • Evaluated plasma sCD36, blood lipids, glucose control (fasting blood glucose, HbA1c), carotid IMT, and MoCA scores in 357 type 2 diabetic patients.
  • Statistical analyses included ANOVA and correlation analyses, with adjustments for relevant clinical characteristics.

Main Results:

  • Patients with lower IMT exhibited lower sCD36 levels and higher MoCA scores.
  • Higher sCD36 levels were associated with increased fasting blood glucose, LDL-C, and carotid IMT.
  • Plasma sCD36 showed a significant positive correlation with carotid IMT (r=0.202, p<0.001) after adjustments.
  • Carotid IMT was inversely associated with MoCA scores (r=0.284, p<0.001) after adjustments.
  • No significant correlation was found between sCD36 and MoCA scores (r=-0.038, p=0.470).

Conclusions:

  • Soluble CD36 (sCD36) is associated with carotid intima-media thickness (IMT) in type 2 diabetic patients.
  • Carotid IMT is inversely correlated with cognitive function in this population.
  • This study did not detect a cross-sectional association between sCD36 levels and cognitive function (MoCA scores).
Abstract

Keywords:
Montreal Cognitive Assessment (MoCA)atherosclerosiscarotid intima-media thicknessdiabetes mellitus type 2soluble CD36

More Related Videos

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology09:33

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Published on: February 7, 2015

16.9K
Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

3.5K

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.3K
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
605
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
476
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.2K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.5K
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
486