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Related Experiment Video

Updated: Feb 23, 2026

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model

Published on: July 3, 2020

Periostin in kidney diseases.

Niki Prakoura¹, Christos Chatziantoniou^2,3

¹Institut National de la Santé Et de la Recherche Médicale UMRS 1155, Tenon Hospital, 4 rue de la Chine, 75020, Paris, France. niki.prakoura@gmail.com.

Cellular and Molecular Life Sciences : CMLS

|September 9, 2017

Summary

Periostin is a key factor in chronic kidney disease progression, driving inflammation and fibrosis. Inhibiting periostin in animal models halted disease advancement, suggesting its potential as a therapeutic target for kidney disease.

Keywords:

Chronic kidney disease Fibrosis Inflammation Periostin Target of therapy

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Last Updated: Feb 23, 2026

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model

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Area of Science:

Nephrology
Molecular Biology
Pathology

Background:

Chronic kidney disease (CKD) lacks curative treatments, necessitating novel therapeutic targets.
Understanding molecular mechanisms is crucial for identifying new diagnostic markers and treatments for kidney diseases.

Purpose of the Study:

To review recent advances on periostin in kidney diseases.
To discuss periostin's potential as a therapeutic target for CKD.

Main Methods:

Literature review of studies on periostin in renal disease.
Analysis of periostin expression in kidney disease patients and animal models.
Evaluation of periostin's role in renal inflammation and fibrosis.

Main Results:

Periostin is expressed by injured kidney cells and correlates with CKD stage and function decline.
Periostin mediates renal inflammation and fibrosis in animal models.
Genetic or pharmacogenetic inhibition of periostin arrested kidney disease progression in animal studies.

Conclusions:

Periostin is a significant mediator in the progression of kidney diseases.
Periostin represents a promising novel therapeutic target for chronic kidney disease.