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Related Experiment Video

Updated: Feb 23, 2026

Author Spotlight: Assessing the Reliability of Doppler Ultrasound in Measuring Leg Blood Flow

Author Spotlight: Assessing the Reliability of Doppler Ultrasound in Measuring Leg Blood Flow

Published on: December 15, 2023

Reference range and variability of Laser-Doppler-Fluxmetry.

C Mrowietz¹, R P Franke², G Pindur¹

¹Institute for Clinical Hemostaseology and Transfusion Medicine, University of Saarland, Homburg/Saar, Germany.

Clinical Hemorheology and Microcirculation

|September 9, 2017

Summary

This summary is machine-generated.

This study establishes reference ranges for the new DOP-system Laser Doppler Fluxmetry (LDF) to reliably assess skin blood flow. Results show no seasonal or daily variation, enabling accurate diagnosis of microcirculatory disorders.

Keywords:

Laser Doppler Flux reference range skin perfusion variability

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Evaluation of Cerebral Blood Flow Autoregulation in the Rat Using Laser Doppler Flowmetry

Evaluation of Cerebral Blood Flow Autoregulation in the Rat Using Laser Doppler Flowmetry

Published on: January 19, 2020

Area of Science:

Biomedical Engineering
Physiology
Medical Diagnostics

Background:

Laser Doppler Fluxmetry (LDF) is a noninvasive technique for measuring skin blood flow, widely used in research and clinical settings.
The new DOP-system offers enhanced capabilities by analyzing frequency spectra across four distinct velocity windows, targeting venules, capillaries, and arteries.
Sufficient evaluation of LDF's diagnostic reliability and effectiveness, including reference ranges and parameter variability, is crucial for clinical applications.

Purpose of the Study:

To evaluate the diagnostic reliability and effectiveness of the new DOP-system Laser Doppler Fluxmetry (LDF).
To establish reference ranges and assess the variability of LDF measurements for accurate interpretation in medical diagnostics and therapy control.

Main Methods:

Four studies were conducted to determine reference ranges in 62 healthy subjects.
Circadian, day-to-day, and yearly variability of LDF measurements were assessed in small subject groups (8 and 6 participants).
Measurements utilized the new DOP-system, analyzing frequency spectra across four velocity windows.

Main Results:

Reference ranges for the DOP-system LDF were established.
No significant dependence of measured data on the day or season of measurement was found.
Circadian and day-to-day variability were evaluated.

Conclusions:

The established reference ranges for the DOP-system LDF enable the diagnosis of microcirculatory disorders.
The lack of seasonal or daily dependence simplifies standardized measurement procedures.
This study provides essential data for the valid interpretation of LDF values in individual patients.