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Is serum high-mobility group box 1 (HMGB-1) level correlated with liver fibrosis in chronic hepatitis B?

Ahmet Cagkan Inkaya1, Nazlim Aktug Demir, Servet Kolgelier

  • 1Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Selçuk University, Konya Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Adiyaman University, Adiyaman Department of Public Health, Faculty of Medicine, Necmettin Erbakan University, Konya Department of Pathology, Adiyaman Education and Research Hospital, Adiyaman Department of Biochemistry, Adiyaman Education and Research Hospital, Adiyaman Department of Biochemistry, Faculty of Medicine, Adiyaman University, Adiyaman, Turkey.

Medicine
|September 9, 2017
PubMed

Insights

Serum high-mobility group box 1 (HMGB1) levels are elevated in early liver injury but do not correlate with fibrosis severity in chronic hepatitis B patients. Further research is needed to understand HMGB1's role in liver disease progression.

Area of Science:

  • Hepatology
  • Immunology
  • Biochemistry

Background:

  • High-mobility group box 1 (HMGB1) is an alarmin involved in virus-triggered liver injury.
  • The association between HMGB1 and liver fibrosis requires further investigation.

Purpose of the Study:

  • To evaluate the association between serum HMGB1 levels and liver fibrosis in chronic hepatitis B (CHB) patients.

Main Methods:

  • A cross-sectional case-control study involving 189 CHB patients and 51 healthy controls.
  • Liver biopsy and modified Knodell scoring were used to assess fibrosis.
  • Serum HMGB1 levels were quantified using ELISA.

Main Results:

  • Mean serum HMGB1 levels were significantly higher in CHB patients than in controls (P=.001).
  • HMGB1 levels showed a non-significant trend towards being higher in advanced fibrosis stages.
  • Fibrosis severity correlated inversely with albumin levels and directly with ALT and HBV DNA levels.

Conclusions:

  • Serum HMGB1 levels increase during the early stages of liver injury.
  • HMGB1 levels are not correlated with the severity of liver fibrosis in CHB patients.
Abstract

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