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Updated: Feb 23, 2026
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Granulocyte-dependent Autoantibody-induced Skin Blistering
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Autoimmune Progesterone Dermatitis Presenting as Stevens-Johnson Syndrome
Sara M Drayer1, Larry R Laufer, Maureen E Farrell
1Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Naval Medical Center San Diego, San Diego, California.
Obstetrics and Gynecology
|September 9, 2017
Summary
Autoimmune progesterone dermatitis causes cyclical skin issues linked to the menstrual cycle. Surgical treatment like oophorectomy may be necessary when medical management fails for this rare condition.
Area of Science:
- Dermatology
- Endocrinology
- Immunology
Background:
- Autoimmune progesterone dermatitis is a rare condition characterized by cyclical skin eruptions.
- Symptoms correlate with the luteal phase of the menstrual cycle, triggered by rising progesterone levels.
Observation:
- A 22-year-old woman experienced symptoms mimicking Stevens-Johnson syndrome.
- Cyclic recurrence of symptoms led to the diagnosis of autoimmune progesterone dermatitis via intradermal progesterone challenge.
Findings:
- The patient remained refractory to medical management for 48 months.
- Definitive treatment with bilateral oophorectomy was ultimately performed.
Implications:
- Autoimmune progesterone dermatitis presents diagnostic challenges due to its rarity and varied clinical manifestations.
- Treatment involves progesterone suppression and trigger avoidance; surgical intervention is considered for refractory cases.
- Bilateral oophorectomy offers a definitive surgical solution for severe, treatment-resistant autoimmune progesterone dermatitis.
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