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A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq
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Genome evolution is driven by gene expression-generated biophysical constraints through RNA-directed genetic

Didier Auboeuf1

  • 1Univ Lyon, ENS de Lyon, Univ Claude Bernard, CNRS UMR 5239, INSERM U1210, Laboratory of Biology and Modelling of the Cell, Site Jacques Monod, Lyon, France.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|September 9, 2017
PubMed
Summary

Cellular processes like RNA and protein synthesis pose risks to DNA stability, potentially leading to toxic aggregates. This review suggests that genetic variations arise to alleviate these constraints, driven by small RNAs and impacting genome evolution.

Keywords:
DNA instabilityRNARNA processingevolutiongene expressiontranslation

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