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Updated: Feb 23, 2026

Single-cell Microfluidic Analysis of Bacillus subtilis
Published on: January 26, 2018
A Life in Bacillus subtilis Signal Transduction
1Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California 92037;
Abstract:
This is a tale of how technology drove the discovery of the molecular basis for signal transduction in the initiation of sporulation in Bacillus subtilis and in bacterial two-component systems. It progresses from genetics to cloning and sequencing to biochemistry to structural biology to an understanding of how proteins evolve interaction specificity and to identification of interaction surfaces by statistical physics. This is about how the people in my laboratory accomplished this feat; without them little would have been done.
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