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Updated: Feb 23, 2026

Closure of a Patent Foramen Ovale PFO: An Intervention Sequence
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Closure of a Patent Foramen Ovale PFO: An Intervention Sequence

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Current Dataset for Patent Foramen Ovale Closure in Cryptogenic Stroke: Randomized Clinical Trials and Observational

Olufunso W Odunukan1, Matthew J Price1

  • 1Division of Cardiovascular Diseases, Scripps Clinic, 9898 Genesee Avenue, La Jolla, CA 92037, USA.

Interventional Cardiology Clinics
|September 10, 2017
PubMed

Insights

Patent foramen ovale (PFO) is common in cryptogenic stroke patients. This review assesses PFO closure

Area of Science:

  • Cardiology
  • Neurology
  • Vascular Medicine

Background:

  • Cryptogenic strokes account for about one-third of all strokes.
  • Patent foramen ovale (PFO) is found in up to 60% of cryptogenic stroke patients, a higher prevalence than in the general population.
  • Potential mechanisms for stroke in PFO patients include paradoxical embolism and in situ thrombosis.

Purpose of the Study:

  • To review and critically evaluate current research.
  • To assess the efficacy and safety of patent foramen ovale closure.
  • To determine the role of PFO closure in preventing recurrent cryptogenic strokes.

Main Methods:

  • Systematic review and critical appraisal of contemporary studies.
  • Analysis of data on PFO closure procedures.
  • Evaluation of stroke recurrence rates and safety outcomes post-closure.

Main Results:

  • Studies indicate a significant association between PFO and cryptogenic stroke.
  • Efficacy data on PFO closure for stroke prevention is being actively investigated.
  • Safety profiles of PFO closure interventions are a key consideration.

Conclusions:

  • Patent foramen ovale closure is a potential strategy for preventing recurrent cryptogenic strokes.
  • Further research is needed to definitively establish the efficacy and optimal patient selection for PFO closure.
  • Balancing the benefits of stroke prevention against procedural risks is crucial.

Keywords:
Cryptogenic strokeParadoxic embolismPatent foramen ovale

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